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KMID : 0357919830170030361
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Korean Journal of Pathology
1983 Volume.17 No. 3 p.361 ~ p.366
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Stein-Leventhal Syndrome with Endometrial Adenocarcinoma -A case report with literature review-
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신형식/Hyun Sik Shin
박성회/안긍환/Seong Hoe Park/Geung Hwan Ahn
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Abstract
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In 1935, Stein and Leventhal first described a syndrome consisting of amenorrhea,
infertility and a pathologic feature of bilateral polycystic ovaries. Though a number of
possible theories regarding etiologic factors have been explored and discussed, the
pathogenic mechanisms are including hypothalamus-pituitary axis, ovarian
steroidogenesis and adrenal factors. Frequently, this syndrome was associated with
endometrial carcinoma or atypical endometrial hyperplasia, Jackson reported 16 cases
(37.2%) of association out of 43 patients of Stein-Leventhal syndrome. A case of
Stein-Leventhal syndrome associated with endometrial adenocarcinoma was presented.
She was a 30-year-old woman with infertility for 5 years and irregular uterine bleeding
for 18 days. She was obese and hirsute, but her clitoris was not enlarged. She generally
showed secondary female sex characteristics except hirsutism. A diagnostic endometrial
curettage showed grade I endometrial adenocarcinoma. Total hystrectomy with bilateal
adenexectomy was done. Ovaries were symmetrically enlarged and disclosed capsular
thickening and multiple subcapsular cystic follicles. Numerous primordial follicles were
noted without any corpus luteum and albicans. The endometrial cavity showed a dark
brown ill defined area in the right fundus, and was confirmed to be endometrial
carcinoma. Literature review on pathogenesis of Stein-Leventhal syndrome and relation
between Stein-Leventhal syndrome and endometrial adenocarcinoma was done.
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